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2020年主要科研成果

 

1.专利情况

序号

专利名称

专利授权号

获准国别

完成人

类型

类别

1

一种靶向CD24单克隆抗体与二乙胺偶氮鎓二醇盐的偶联物及其应用

ZL201810192838.3

中国

张娟,黄张建,张鑫荣,王旻,马招兄,徐瑶

发明专利

合作完成—第一人

2

抗人Delta like 4单克隆抗体及其应用

ZL201510946100.8

中国

王旻,吴旻,许卓斌,贾雪莲,王世静,王泽根,张娟,罗晨

发明专利

合作完成—第一人

3

叶黄素及其衍生物在制备抗脑胶质瘤药物中的应用

ZL201810920129.2

中国

刘煜,闫忠辉,李小平,别雨薇,纪雪梅

发明专利

合作完成—第一人

5

一种莱鲍迪苷KA的制备方法

ZL201710388463.3

中国

吴旭日,陈依军,金月

发明专利

合作完成—第一人

6

抗hTNF-α全人源抗体及其用途

ZL201711126478.9

中国

姚文兵,童玥,钟升威,田浤,高向东

发明专利

合作完成—第二人

7

抗菌肽MSI-1及其用途

ZL201710700963.6

中国

周长林,魏杉杉,杨晓倩,马菱蔓,刘含含,贾源宾,窦洁

发明专利

合作完成—第一人

8

去亚甲基四氢小檗碱在制备预防或治疗酒精性肝病和非酒精性肝病药物中的应用

ZL201811339367.0

中国

张玉彬,张元强,朱倩倩,邱贞,李青霞,张淼,潘杉,赵亚星,闻婧

发明专利

合作完成—第一人

9

与PD-L1结合的重复域锚定蛋白及其用途

ZL201710716986.6  

中国

高向东,宋潇达,陈晓菲,刘利,田浤,姚文兵

发明专利

合作完成—第一人

10

一种具有抗肿瘤、抗炎症和治疗眼科疾病功能的融合蛋白及其制备方法和应用

ZL201610034225.8

中国

徐寒梅,于健

发明专利

合作完成—第一人

11

抗菌多肽EC1-17KV及其用途

ZL2017108756538

中国

马菱蔓,周丽,孙鹏博,史翔宇,林健,安胜祥,窦洁,周长林

发明专利

合作完成—第一人

12

重组聚多肽及其应用

ZL201510675827.7

中国

姚文兵,尹骏,高向东,田浤,包立晨,邵美

发明专利

合作完成—其它

13

木聚糖酯化产物在制备预防或治疗炎症性疾病及癌症药物中的应用

ZL201711433322.5

中国

尹鸿萍,吕杨,查正其,王莹,王苏妍

发明专利

合作完成—第一人

14

叶酸受体α特异性结合肽4及其应用

ZL201710649314.8

中国

王旻,邱郑,徐祎凤,邢黎军,王红

发明专利

合作完成—第一人

15

叶酸受体α特异性结合肽1及其应用

ZL201710649453.0

中国

邱郑,王旻,徐祎凤,邢黎军,王红

发明专利

合作完成—第一人

16

叶酸受体α特异性结合肽5及其应用

ZL201710649315.2

中国

王旻,邱郑,徐祎凤,邢黎军,王红

发明专利

合作完成—第一人

17

一种寡肽及其衍生物和应用

ZL201810245237.4

中国

牛淼淼,徐寒梅

发明专利

合作完成—第二人

18

一种肿瘤靶向性多肽

ZL201710960927.3

中国

劳兴珍,郑珩,吴扬生

发明专利

合作完成—第一人

19

一种具有镇痛活性的多肽及其应用

ZL201711122014.0

中国

徐寒梅,戚微岩,刘晨,吴鹏翔

发明专利

合作完成—第一人

20

一种靶向ARTN的单链抗体、制备方法及应用

ZL201711074804.6

中国

杨勇,张娟,卡马尔·哈立德·法尔汉·褐泽姆,王旻,张鑫荣,蒋家豪,孙福谋,王阳,杜晓典

发明专利

合作完成—第二人

21

一种高活性抑制PCSK9表达的微小RNA及其用途

ZL201811635325.1

中国

谭树华,陈雪梅,裴苏俐,周秋景,徐梦龙

发明专利

合作完成—第一人

22

抗体修饰盐酸抗肿瘤药物脂质体、其制备方法及应用

ZL201810672398.1

中国

张娟,刘雅利,王旻,蔡佳玲,王阳,王斐

发明专利

合作完成—第一人

23

一种尿酸酶外用凝胶制剂、其制备方法及用

201811065580 .7

中国

陈建华,王玉霞

发明专利

合作完成—第一人

24

枸杞芽茶的有效部位及其制备方法、应用

ZL201810677845.2

中国

张玉彬,栾倩,哈成勇,邱贞,樊毅,张淼,张元强,许露露

发明专利

合作完成—第一人

25

辅助性表位肽及其应用

ZL2018104085863

中国

姚文兵,田浤,徐艺,何羽,高向东

发明专利

合作完成—第二人


2.发表论文、专著情况

序号

论文或

专著名称

作者

刊物、出版社名称

卷、期

(或章节)、页

类型

类别

1

Systemic nanoparticle-mediated delivery of pantetheinase Vanin-1 regulates lipolysis and adiposity in abdominal white adipose tissue

Chang Liu

Advanced Science

7(14)

SCI(E)

合作完成其它

2

Micropeptide MIAC Inhibits HNSCC Progression by Interacting with Aquaporin 2

Hanmei Xu*

Journal of the American Chemical Society

142(14): 6708-6716

SCI(E)

合作完成其它

3

Enhanced Safety and Antitumor Efficacy of Switchable Dual Chimeric Antigen Receptor-Engineered T Cells against Solid Tumors through a Synthetic Bifunctional PD-L1-Blocking Peptide

Weiyan Qi,Weiguang Li,Jianpeng Xue,Hanmei Xu*

Journal of the American Chemical Society

142(44): 18874-18885

SCI(E)

合作完成其它

4

Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

Jing Li*,E-Hu Liu*

Science Advances

6:eaax6208

SCI(E)

合作完成其它

5

Obesity-induced overexpression of miR-802
impairs insulin transcription and secretion

Liang Jin*

Nature communications

11:1822

SCI(E)

合作完成其它

6

Emerging agents that target signaling pathways in cancer stem cells.

Xi Tao,Zheng Lufeng

J Hematol Oncol

13(1):60

SCI(E)

合作完成其它

7

RNA-binding proteins in tumor progression

Zheng Lufeng

J Hematol Oncol

13(1):90

SCI(E)

合作完成其它

8

Mice deficient in UXT mimic features of retinitis pigmentosa

Haiyang Hu*,Chen Wang*

Autophagy

 

SCI(E)

合作完成其它

9

Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation

Haiyang Hu*,Chen Wang*

Autophagy

暂无

SCI(E)

合作完成其它

10

Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice

Liang Jin*,Defu Zeng*

Proc Natl Acad Sci U S A

2020 Nov 23;202012389.

SCI(E)

合作完成其它

11

Potent antibacterial activity of MSI-1 derived from the magainin 2 peptide against drug-resistant bacteria

Ma Lingman

Theranostics

10(3):1373-1390

SCI(E)

合作完成第一人

12

Modulation of the astrocyte-neuron lactate shuttle system contributes to neuroprotective action of fibroblast growth factor 21

Xiangdong Gao,Song Chen

Theranostics

10(18):8430-8445

SCI(E)

合作完成其它

13

Nuclear cGAS Functions Non-Canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

Chen Wang*

Cell Reports

已接收,12月中旬online

SCI(E)

合作完成其它

14

Polysaccharide catabolism by the human gut bacterium-Bacteroides thetaiotaomicron: advances and perspectives

Gao Xiangdong*,Liu Wei*

Critical Reviews in Food Science and Nutrition

 

SCI(E)

合作完成其它

15

An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice

Xiangdong Gao,Wenbing Yao

Br J Pharmacol

177(15):3473-3488.

SCI(E)

合作完成其它

16

Linking m6A to Wnt signaling

Xiao-Min Liu,Shu-Bing Qian*

EMBO Reports

21(4):e50097

SCI(E)

合作完成第一人

17

PDL1-targeted vaccine exhibits potent antitumor activity by simultaneously blocking PD1/PDL1 pathway and activating PDL1-specific immune responses.

Tian H

Cancer Letters

476:170-182

SCI(E)

合作完成第一人

18

A PD-1 peptide antagonist exhibits potent anti-tumor and immune

Min Wang*,Zheng Qiu*

Cancer Letters

493 (2020):91-101

SCI(E)

合作完成其它

19

Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation.

Jin L*

Diabetologia

63(4):811-824.

SCI(E)

合作完成其它

20

Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation

Ling Li,Liang Jin*

Diabetologia

63,811-824

SCI(E)

合作完成其它

21

Tumor-derived EV-encapsulated miR-181b-5p induces angiogenesis to foster tumorigenesis and metastasis of ESCC

YingWang,Hanmei Xu*

Molecular Therapy - Nucleic Acids

20:421-437

SCI(E)

合作完成第一人

22

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity

Xi Tao,Zheng Lufeng

Mol Ther Nucleic Acids

21:527-541

SCI(E)

合作完成其它

23

Therapeutic application of adipose-derived
stromal vascular fraction in diabetic foot

Liang Jin*

Stem Cell Research & Therapy

(2020)11:394-401

SCI(E)

合作完成其它

24

SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.

刘畅,陈思禹

Molecular Metabolism

32:85-96

SCI(E)

合作完成其它

25

Long noncoding RNA TTN-AS1 facilitates tumorigenesis and metastasis by maintaining TTN expression in skin cutaneous melanoma

Ying Wang,Hanmei Xu*

Cell Death and Disease

11(8):664

SCI(E)

合作完成第一人

26

Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas

Mengwei Li,Hanmei Xu*

Cell Death & Disease

11(8):1-12

SCI(E)

合作完成其它

27

Tumor necrosis factor α inhibition overcomes immunosuppressive M2b macrophage-induced bevacizumab resistance in triple-negative breast cancer.

Yu Liu*, Xuemei Ji*

cell death &disease

11(993):1-13

SCI(E)

合作完成第一人

28

Synergistic anti-fibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells

Chen XG,Zhang D,Wang Y

Cell Death Dis

11(5):402

SCI(E)

合作完成第一人

29

A visible and near-infrared dual-fluorescent probe for discrimination between Cys/Hcy and GSH and its application in bioimaging

Hongping Yin*,Zhenwei Yuan*

BIOMATERIALS SCIENCE

8:5994-6003

 

合作完成—其它

30

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

Hanmei Xu*,Jialiang Hu*

Journal of Neuroinflammation

17(1):126

SCI(E)

合作完成—其它

31

Silk fibroin hydrogel as mucosal vaccine carrier:
induction of gastric CD4+TRM cells mediated by
inflammatory response induces optimal immune
protection against Helicobacter felis

Tao Xi,Yingying Xing

Emerging Microbes & Infections

9(1):2289-2302

SCI(E)

合作完成—其它

32

Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption.

Lingman Ma,Changlin Zhou*

EBioMedicine

55:102775

SCI(E)

合作完成—第一人

33

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice.

Xu Hanmei*,Hu Jialiang*

J Neuroinflammation

17(1):126-144

SCI(E)

合作完成—其它

34

Therapeutic application of adipose-derived stromal vascular fraction in diabetic foot

Liang Jin*

Stem Cell Research & Therapy

11(1):394.

SCI(E)

合作完成—其它

35

AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle

Chen M,Sanchis D,Yan F,Ye J*.

Clin Sci (Lond)

134(17):2381-2398

SCI(E)

合作完成—其它

36

miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1

Yanfeng Zhang,Liang Jin,Yi Pan

Am J Cancer Res

10(1):38-59

SCI(E)

合作完成—其它

37

Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models

Min Wang*,Min Wu*

American Journal of Cancer Research

10(8):2387-2408

SCI(E)

合作完成—其它

38

miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1

Pandi ,Liang Jin*,Yi Pan*

AMERICAN JOURNAL OF CANCER RESEARCH

10(1):38-59

SCI(E)

合作完成—其它

39

Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Minyi Qian,Haiyang Hu,Ying Yao

Liver International

40(3):622-637

SCI(E)

合作完成—其它

40

Immunomodulatory Activity-Guided Isolation and Characterization of a Novel Polysaccharide From Atractylodis Macrocephalae Koidz

Wei Guo

Int J Biol Macromol

161:514-524

SCI(E)

合作完成—其它

41

An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis

Zhengqi Zha,Ying Wang,Hongping Yin

international journal of biological macromolecules

156(2020):1217-1233

SCI(E)

合作完成—其它

42

Isolation, structural characterization of polysaccharide from Cephalosporium sinensis mycelia and its anti-nephritic effects in adenine-induced CKD rats

Zhengqi Zha,Hongping Yin

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

155:340-349

SCI(E)

合作完成—其它

43

The α-D-glucan from marine fungus Phoma herbarum YS4108 ameliorated mice colitis by repairing mucosal barrier and maintaining intestinal homeostasis

Liu Wei,Yao Wenbing*,Gao Xiangdong*

International Journal of Biological Macromolecules

149: 1180-1188

SCI(E)

合作完成—其它

44

miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1.

 Jin L*,Pan Y*

Am J Cancer Res

10(1):38-59

SCI(E)

合作完成—第一人

45

Characterization of a polysaccharide from Eupolyphaga sinensis walker and its effective antitumor activity via lymphocyte activation.

Zhou Changlin*

International journal of biological macromolecules

162:31-42

SCI(E)

合作完成—其它

46

An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo.

,Jie Dou,Changlin Zhou*,Lingman Ma*

Biochemical pharmacology

172:113746

SCI(E)

合作完成—其它

47

A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac lipotoxicity induced mitochondria dysfunction

Xiangdong Gao 2,Wenbing Yao 3

Biochem Pharmacol

182:114209

SCI(E)

合作完成—其它

48

Enhanced oral bioavailability of magnolol via mixed micelles and
nanosuspensions based on SoluplusVR -Poloxamer 188

Weiguang Li*

DRUG DELIVERY

27(1):1010-1017

SCI(E)

合作完成—其它

49

NSUN5 facilitates viral RNA recognition by RIG-I receptor

Haiyang Hu,Chen Wang*,Juanjuan Zhu*

Journal of Immunology

205(12):3408-3418

SCI(E)

合作完成—其它

50

Antiangiogenic activity of terpenoids from Euphorbia neriifolia Linn

Hanmei Xu*

Bioorganic Chemistry

96:103536

SCI(E)

合作完成—其它

51

Antibody-Drug Conjugates: A Comprehensive Review

Juan Zhang*

Molecular Cancer Research

18(1):3-19

SCI(E)

合作完成—其它

52

Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide

Wei Zhu,Weihua Chu*

Biomedicine & Pharmacotherapy

121:109591

SCI(E)

合作完成—第一人

53

AntiIL-12/23 p40 antibody attenuates chronic graft-versus-host disease with lupus nephritis via inhibiting Tfh cell in mice

Xiangdong Gao,Wei Guo.

Biomed Pharmacother

129:110396

SCI(E)

合作完成—其它

54

Chronopharmacology of simvastatin on hyperlipidaemia in high-fat diet-fed obese mice

刘畅

Journal of Cellular and Molecular Medicine

24(18):11024-11029

SCI(E)

合作完成—其它

55

Potential therapeutic role of fibroblast growth factor 21 in neurodegeneration: evidence for ameliorating parkinsonism via silent information regulator 2 homolog 1 and implication for gene therapy

Wenbing Yao,Xiangdong Gao,Song Chen

Neuropharmacology

181:108335

SCI(E)

合作完成—其它

56

Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/ T chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling

Yubin Zhang*,Ruiyan Li*

phytomedicine

68:153182

SCI(E)

合作完成—其它

57

Enzymatic Monoglucosylation of Rubusoside and the Structure-Sweetness/Taste Relationship of Monoglucosyl Derivatives

Yijun Chen*,Xuri Wu*

Journal of Agricultural and Food Chemistry

68(32):8702-8709

SCI(E)

合作完成—其它

58

Antimicrobial and Anti-Quorum Sensing Activities of Phlorotannins From Seaweed (Hizikia fusiforme)

Jiali Tang,Wenqian Wang,Weihua Chu

Frontiers in Cellular and Infection Microbiology

10:586750

SCI(E)

合作完成—第一人

59

BCMA-targeting Bispecific Antibody That Simultaneously Stimulates NKG2D-enhanced Efficacy Against Multiple Myeloma

Min Wang*,Juan Zhang*

Journal of immunotherapy

43(6):175-188

SCI(E)

合作完成—其它

60

Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes

刘畅

Journal of Endocrinology

247(2):183-195

SCI(E)

合作完成—其它

61

Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution

Xiao-Min Liu*,Jun Zhou*

Journal of Molecular Cell Biology

mjaa057

SCI(E)

合作完成—第一人

62

Integration of peripheral circadian clock and energy metabolism in metabolic tissues.

张岩晨,张雯翔,刘畅

Journal of Molecular Cell Biology

12(7):481-485

SCI(E)

合作完成—其它

63

Efcient Biocatalytic Preparation of
Rebaudioside KA: Highly Selective
Glycosylation Coupled with UDPG
Regeneration

Yijun Chen*,Xuri Wu*

Scientific reports

10(1):6230

SCI(E)

合作完成—其它

64

Evaluation of protein arginine deiminase-4 inhibitor in TNBS- induced colitis in mice

Fengjie Huang,Jie Wu*

International Immunopharmacology

84:106583

SCI(E)

合作完成—其它

65

Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced
by CCl4 in mice

Xiaochuan Hu,Ying Wang*

International Immunopharmacology

79(1):106157

SCI(E)

合作完成—其它

66

CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages

Hanmei Xu*,Jialiang Hu*

International Immunopharmacology

78: 106046

SCI(E)

合作完成—其它

67

Hsa-miR-140-5p down-regulates LDL receptor and attenuates LDL-C uptake in human hepatocytes

Shuhua Tan

Atherosclerosis

297:111119

SCI(E)

合作完成—其它

68

Experimental Rodent Models of Cardiovascular Diseases

Ming Ding*,Quanyi Wang*

Frontiers in Cardiovascular Medicine

7:588075

SCI(E)

合作完成—其它

69

Inhibitory effects of canagliflozin on pancreatic cancer are mediated via the downregulation of glucose transporter1 and lactate dehydrogenase A

Zhou Changlin*

International journal of oncology

Online ahead of print

SCI(E)

合作完成—其它

70

Demethyleneberberine attenuates concanavalin A-induced autoimmune
hepatitis in mice through inhibition of NF-κB and MAPK signaling

Ruiyan Li,Yubin Zhang

International Immunopharmacology

80 (2020): 106137

SCI(E)

合作完成—其它

71

Chip-based serum proteomics approach to reveal the potential protein markers in the sub-acute stroke patients receiving the treatment of Ginkgo Diterpene Lactone Meglumine Injection

Xi Tao

J Ethnopharmacol

260:112964

SCI(E)

合作完成—其它

72

Bioactive structural basis of proteoglycans from Sarcandra glabra based on spectrum-effect relationship

Gao Xiangdong*,Liu Wei*

Journal of Ethnopharmacology

259:112941

SCI(E)

合作完成—其它

73

Preparation of RGD4C fused anti-TNFα nanobody and inhibitory activity on triple-negative breast cancer in vivo

Xuemei Ji #,Nannan Kang,Song Huang,Yu Liu *

Life Sciences

260(2020):118274

SCI(E)

合作完成—第一人

74

Improving High-fat Diet-induced Obesity and Fatty Liver by Adipose Tissue Targeted Delivery of Vascular Endothelial Growth Factor-B

Yue Tong,Xiangdong Gao*,Wenbing Yao*

Life Sciences

253:117677

SCI(E)

合作完成—第一人

75

Gm15575 functions as a ceRNA to up-regulate CCL7 expression through sponging miR-686 in Th17 cells

Xiangdong Gao,Wei Guo

Molecular Immunology

125:32-42

SCI(E)

合作完成—其它

76

Endogenous circadian time genes expressions in the liver of mice under constant darkness.

刘畅

BMC Genomics

21(1):224

SCI(E)

合作完成—其它

77

Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo

Changlin Zhou*,Min Guo*

Virologica Sinica

Online ahead of print

SCI(E)

合作完成—其它

78

Anti-tumor effect of single-chain antibody to Reg3a in colorectal cancer

Z Yu, W Wang M,Luo C*,Yu L*.

Experimental Cell Research

396(1):112278

SCI(E)

合作完成—其它

79

CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages.

Hanmei Xu*,Jialiang Hu*

Int. Immunopharmacol.

78: 106046-53

SCI(E)

合作完成—其它

80

Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Local Antibody Response

Tao Xi,Yingying Xing

Journal of Immunology Research

2020(11)

SCI(E)

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81

Novel Peptide CM 7 Targeted c-Met with Antitumor Activity

Ying Wang,Hanmei Xu*

Molecules

25(3):451-470

SCI(E)

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82

MiR-375 inhibits the stemness of breast cancer cells by blocking the JAK2/STAT3 signaling

Xi Tao,Zheng Lufeng

Eur J Pharmacol

884:173359

SCI(E)

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83

Inhibitory potential of Low Molecular Weight Heparin in Cell adhesion; Emphasis on Tumor Metastasis

ShuyingHe*

European Journal of Pharmacology

 

SCI(E)

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84

First Identification of Human Adenovirus Subtype 21a in China with MinION and Illumina sequencers

Juanjuan Zhu

Frontiers in Genetics

11,285

SCI(E)

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85

Inhibitory Activity of Honeysuckle Extracts against Inuenza A Virus In Vitro /and In Vivo

Changlin Zhou,Min Guo

Virologica Sinica

 

SCI(E)

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86

Gradient degradable nerve guidance conduit with multilayer structure prepared by electrospinning.

Liting Yu,Wanheng Zhang,Yin Jiang,Changying Guo

Materials Letters

276:1-4

SCI(E)

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87

The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test

Jialiang Hu,Hanmei Xu*

European Journal of Pharmacology

870(2020):172909

SCI(E)

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88

Potential Use of C-phycocyanin in Non-Alcoholic Fatty Liver Disease

Tingting Li,Yu Ou*

Biochem Biophys Res Commun

526(4): 906-912

SCI(E)

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89

Design and development of a high temperature stable sweet protein base on monellin

HongTian,WenbingYao,XiangdongGao

Process Biochemistry

89:29-36

SCI(E)

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90

Sini decoction ameliorates interrelated lung injury in septic mice by modulating the composition of gut microbiota.

Wang W,Chen Q,Yang X,Wu J,Huang F

Microb Pathog

2020(140):103956-13

SCI(E)

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91

Isolation and preliminary screening of potentially probiotic Weissella confusa strains from healthy human feces by culturomics

Wenqian Wang,Wugao Liu,Weihua Chu*

Microbial Pathogenesis

147,104,356

SCI(E)

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92

Comparative proteomic analysis of sensitive and multi-drug resistant Aeromonas hydrophila isolated from diseased fish

Wei Zhu,Shuxin Zhou,Weihua Chu*

Microbial Pathogenesis

139,103,930

SCI(E)

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93

Antimicrobial activities of peptide Cbf-K16 against drug-resistant Helicobacter pylori infection in vitro and in vivo.

Meiling Jiang,Lingman Ma,Jie Dou,Changlin Zhou*

Microbial pathogenesis

138:103847

SCI(E)

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94

Modified Thymosin Alpha 1 Distributes and Inhibits the Growth of Lung Cancer in Vivo

Heng Zheng*,Xingzhen Lao*

ACS Omega

5,18,1037410381

SCI(E)

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95

Neutrophil-to-Lymphocyte Ratio Is
Independently Associated With
Severe Psychopathology in
Schizophrenia and Is Changed by
Antipsychotic Administration: A
Large-Scale Cross-Sectional
Retrospective Study

Weiguang Li*,Hong Shen*

Frontiers in Psychiatry

11:581061

SCI(E)

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96

Antifungal activity of peptide MSI-1 against Cryptococcus neoformans infection in vitro and in murine cryptococcal meningoencephalitis

Ma Lingman

Peptides

130:170334

SCI(E)

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97

Acute enterovirus infections significantly alter host cellular DNA methylation status

Rong-yue Cao*

Infection, Genetics and Evolution

80:1-6

SCI(E)

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98

Activation of RAW264.7 macrophage by Exopolysaccharide from Aphanothece halaphytica (EPSAH) and the underlying mechanisms.

Yu Ou

Fundam Clin Pharmacol

34(5):591-602

SCI(E)

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99

Recent advances in fluorescence resonance energy transfer-based probes in nucleic acid diagnosis

Zheng H

Anal. Methods

12,884

SCI(E)

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100

Riboflavin Is Directly Involved in N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases

Xuri Wu*,Yijun Chen*

ChemBioChem

21(16):2297-2305

SCI(E)

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101

Sinomenine attenuates septic-associated lung injury through the Nrf2-Keap1 and autophagy.

Wang W,Yang X,Chen Q,Guo M,Wang J,Huang F

J Pharm Pharmacol

722(2):13202-13

SCI(E)

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102

Applications of machine-learning methods for the discovery of NDM-1 inhibitors

Lao XZ,Zheng H

Chem Biol Drug Des.

96(5):1232-1243

SCI(E)

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103

Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview

Juan Zhang*

Immunologic Research

68(6):325-339

SCI(E)

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104

The effects of Bacillus cereus QSI-1 on intestinal barrier function and mucosal gene transcription in Crucian carp (Carassius auratus gibelio)

Weihua Chu*

Aquaculture Reports

171,100,356

SCI(E)

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105

Recent advances of long noncoding RNAs involved in the development of multiple sclerosis

GUO Wei

Chin J Nat Med

18(1): 36-46.

SCI(E)

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106

Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15

Rong-Yue Cao*

Biotechnology Letters

 

SCI(E)

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107

Shifts in the gut microbiota of mice in response to dexamethasone administration

Haichao Zhao,Xueyuan Jiang,Weihua Chu*

International Microbiology

23,565-573

SCI(E)

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108

Anti-quorum sensing activity of Forsythia suspense extract against Chromobacterium violaceum by targeting CviR receptor

Xiyi Zhuang,An Zhang,Weihua Chu*

International Microbiology

23,215-224

SCI(E)

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109

Deep Learning in the Study of Protein-Related Interactions

Shi C,Chen JX,Kang XY,Zhao GL,Lao XZ,Zheng H

Protn and peptide letters

27(5):359-369

SCI(E)

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110

Prediction and Analysis of Key Protein Structures of 2019-nCoV.

Qihao Li,Wen Peng,Yu Ou*

Future Virol

 

SCI(E)

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111

characterization of venoms of deinagkistrodon acutus and bungarus multicinctus using proteomics and peptidomics

孔毅*

current proteomics

17:241-254

SCI(E)

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112

Biliary microbial structure of gallstone patients with a history of endoscopic sphincterotomy surgery

Hongzhang Shen#,Juanjuan Zhu#

Frontiers Cellular and Infection Microbiology

 

SCI(E)

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113

Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p

Xiaomin Liu

Frontiers in Genetics

11,838

SCI(E)

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114

Higher expression of miR-150-5p promotes tumorigenesis by suppressing LKB1 in non-small cell lung cancer

QianLi

Pathology - Research and Practice

216(11):153145

SCI(E)

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115

Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions

QianLi,Hao-Jie Zhu

Drug Metabolism and Disposition January

48(1):31-40

SCI(E)

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116

离子通道类镇痛药物作用机制及研究进展

于瑞河,戚微岩,刘晨,高新梅,徐寒梅*

药学进展

44 (1): 56-65

北大中核心

合作完成—其它

117

寻找解决方案——中国的下一代肿瘤免疫研究

张娟

药学进展

44 (1):66-80

北大中核心

合作完成—其它

118

哺乳动物细胞灌流培养工艺开发与优化

曹荣月*

生物工程学报

36(06):1041-1050

北大中核心

合作完成—其它

119

环氧树脂固定化环状芽孢杆菌糖氨基转移酶的研究

李谦*,崔莉

扬州大学学报(农业与生命科学版)

2020(02):9-15.

北大中核心

合作完成—其它

120

金黄色葡萄球菌核酸酶对2,4,6-三硝基苯磺酸诱导的小鼠结肠炎的保护作用

金亮*,吴洁*

中国药科大学学报

51(2):198-205

北大中核心

合作完成—其它

121

构建噬菌体展示抗体库过程中电穿孔法的条件优化

徐寒梅*

中国生物工程杂志

40(4):42-48

北大中核心

合作完成—其它

122

髓系细胞TGF-beta1基因缺失增加小鼠对结肠炎的易感性

奚涛,邢莹莹

免疫学杂志

4:312-318

北大中核心

合作完成—其它

123

CD47 相关信号通路及其与相关疾病关系的研究进展

葛闯,胡加亮,徐寒梅*

药学进展

44(5):371-378

北大中核心

合作完成—其它

124

环状RNA与2型糖尿病关系及其临床应用

张方方,金亮*

中国药科大学学报

51(03):374-378

北大中核心

合作完成—其它

125

miR-802靶向Hnf1B抑制胰岛素分泌的作用研究

王丹维,张方方,金亮*,吴洁*.

中国药科大学学报

51(01):99-106

北大中核心

合作完成—其它

126

应用于眼部治疗的纳米技术药物研究进展

徐寒梅,胡加亮*,薛建鹏*

药学进展

44(06):459-465

北大中核心

合作完成—其它

127

靶向生物钟的小分子化合物的筛选与疾病治疗

焦雄,孙琛,刘畅

中国生物化学与分子生物学学报

36(07):734-747

北大中核心

合作完成—其它

128

TGFB信号通路调节胰岛β细胞增殖的功能研究

刘廷生,张方方,金亮*

中国细胞生物学学报

42(08):1332-1339

北大中核心

合作完成—其它

129

能量代谢关键调控因子PGC-1α的研究进展

张雯翔,刘 畅,陈思禹*

生理学报

 

北大中核心

合作完成—其它

130

细胞焦亡与代谢性疾病的研究进展

张雯翔,刘畅*,陈思禹*

中国细胞生物学学报

42(7):1247–1254

北大中核心

合作完成—其它

131

高通量灌流培养模型在生物工艺开发中的应用研究

曹荣月*

中国生物工程杂志

40(08):63-73

北大中核心

合作完成—其它

132

基于DNA的纳米材料在肿瘤治疗领域的研究进展

尹骏,姚文兵,高向东*

中国药科大学学报

51(04):406-417

北大中核心

合作完成—其它

133

PD-1/PD-L1免疫检查点抗体
药物制剂稳定性开发

徐寒梅*

中国生物工程杂志

40(10):35-42

北大中核心

合作完成—其它

134

达托霉素高产菌株选育及发酵条件优化

王一芩,曹荣月*

中国抗生素杂志

 

北大中核心

合作完成—其它

135

辅助受体在RIG-Ⅰ/MDA5抗病毒信号通路中的作用

王琛*,朱娟娟

现代免疫学

40(6):516-522

北大中核心

合作完成—其它

136

重组腺相关病毒2,6,8,9 型玻璃体腔注射
在小鼠视网膜中的趋向性表达

李泰明

中华实验眼科杂志

38(5):381-387

北大中核心

合作完成—第一人

137

光照与哺乳动物生理稳态

张雯翔,刘畅,陈思禹*

生物化学与生物物理进展

 

北大中核心

合作完成—其它

138

SWI/SNF染色质重塑复合物亚基Baf60a调控能量代谢稳态的研究进展

张雯翔,刘畅,陈思禹*

生物工程学报

 

北大中核心

合作完成—其它

139

突变型NDUFS7质粒的构建及其对神经细胞的影响

高向东,陈松

中国药科大学学报

51(5):599-606

北大中核心

合作完成—其它

140

靶向cGAS-STING信号通路药物的研究进展

梅家豪,洪泽,王琛*

中国药科大学学报

51(3):249-259

北大中核心

合作完成—其它

141

泛素家族介导的蛋白质降解和细胞自噬

王琛,王琳芳

科学出版社

 

中文专著

合作完成—其它

142

生物化学实验

刘煜,卞筱泓,纪雪梅,宋潇达

高等教育出版社 高等教育电子音像出版社

 

中文专著

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143

新药非临床研究与开发

徐寒梅,沈子龙,薛建鹏,李伟光,陆园园,戚微岩,廖建民

中国医药科技出版社

 

中文专著

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144

传染病诊疗与社区防控指南

朱娟娟,汪春晖,张锦海,叶福强

苏州大学出版社

 

中文专著

合作完成—第一人

145

生物化学与分子生物学

张玉彬,刘煜,叶俊梅,赵文峰

人民卫生出版社

 

中文专著

合作完成—第一人

146

微生物学

周长林

中国医药科技出版社

 

中文专著

独立完成

147

微生物学实验与指导

周长林

中国医药科技出版社

 

中文专著

独立完成

148

生物制药工艺学实验与指导

何书英,刘玮,姬晓南,王全逸,童玥

中国医药科技出版社

 

中文专著

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149

分子与细胞生物学实验与指导  

谭树华,郭薇,田浤,朱娟娟,邱郑,张娟,陈松,周君,郑珩

中国医药科技出版社

 

中文专著

合作完成—第一人

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