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2021年主要科研成果

 


1.专利情况

序号

专利名称

专利授权号

获准国别

完成人

类型

类别

1

一种多肽用于制备预防或治疗脂肪肝病药物的用途

ZL201710539987.8

中国

金亮

发明

专利

合作完成-第一人

2

一种2型糖尿病的诊断引物及试剂盒、以及非编码RNA分子标志物的应用

ZL201910259705.8

中国

金亮

发明

专利

合作完成-第一人

3

胰岛长链非编码RNA 1810019D21Rik及其应用

ZL201810305264.6

中国

金亮

发明

专利

合作完成-第一人

4

口服降糖肽、其脂肪酸衍生物及用途

ZL2019107475199

中国

高向东

发明

专利

合作完成-第一人

5

多肽及其应用

ZL201810408624.5

中国

高向东

发明

专利

合作完成-第一人

6

一株高产蛋白酶的巴布维红酵母

ZL2018111702966

中国

储卫华

发明

专利

合作完成-第一人

7

一种以复合纳米材料为载体的口服给药系统

ZL201711334826.1

中国

邢莹莹

发明

专利

合作完成-第二人

8

茜草科类型环肽化合物在制备cGAS-STING信号通路激活剂的药物中的应用

ZL 2020 1 0347027.3

中国

王琛

发明

专利

合作完成-第二人

9

一种土鳖虫多糖的结构及其用途

ZL201910987685.6

中国

周长林

发明

专利

合作完成-第一人

10

用于检测三甲胺产生基因的引物对及试剂盒

ZL201811203027.5

中国

李菁

发明

专利

合作完成-第一人

11

用于检测丁酸合成基因的引物对及试剂盒

ZL201811203026.0

中国

李菁

发明

专利

合作完成-第一人

12

干扰素突变体及干扰素突变体融合抗体及其制备方法、应用

ZL201811027088.0

中国

张娟

发明

专利

合作完成-第一人

13

抗菌多肽Pb2-1或PCL-1及其制备方法和应用

ZL201910787413.1

中国

周长林

发明

专利

合作完成-第一人

14

一种具有免疫检查点拮抗活性的多肽及其应用

ZL201810912936.X

中国

徐寒梅

发明

专利

合作完成-第一人

15

基质金属蛋白酶抑制性多肽金纳米颗粒组合物及其应用、制备方法

CN201811503478.0

中国

薛建鹏

发明

专利

合作完成-第一人

16

新型罗汉果苷衍生物及其用途

ZL201810866066.7

中国

吴旭日

发明

专利

合作完成-第一人

17

抗PD-1单克隆抗体及其应用

ZL201810108897.8

中国

邱郑

发明

专利

合作完成-第一人

18

一种枸杞叶有效成分胶囊及其制备方法

ZL20191132899.X

中国

张玉彬

发明

专利

合作完成-第一人

19

麦冬皂苷D在制备治疗代谢综合征药物上的应用

ZL202010371078.X

中国

刘畅

发明

专利

合作完成-第二人

20

一种脑部靶向转铁蛋白受体的单链抗体及应用

ZL201710332943.8

中国

刘煜

发明

专利

合作完成-第一人

21

HIGH-ACTIVITY LONG-ACTING HYPOGLYCEMIC FUSION PROTEIN AS WELL AS PREPARATION METHOD AND MEDICAL APPLICATION THEREOF

US11078250B2

 

美国

谭树华

发明

专利

合作完成-第一人


2.发表论文、专著情况

序号

论文或

专著名称

作者

刊物、出版社名称

卷、期

(或章节)、页

类型

类别

1

Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes

王颖

Signal Transduction and Targeted Therapy

6(1): 1-13

SCI(E)

a

2

Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

陆美玲

NUCLEIC ACIDS RESEARCH

49(17):9938-9952

SCI(E)

a

3

DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides

郑珩

Nucleic Acids Res

Aug 14:gkab651

SCI(E)

a

4

The long non-coding RNA beta Faar regulates islet beta-cell function and survival during obesity in mice

金亮

 NATURE COMMUNICATIONS

12(1):3997

SCI(E)

a

5

PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity

梁宏伟

Genome Biol

22(1):104

SCI(E)

b

6

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice.

张雯翔

Biomaterials

278: 121183

SCI(E)

b

7

The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer

王中原

Theranostics

11(9):4421-4435

SCI(E)

a

8

miR-23a/b suppress cGAS-mediated innate and autoimmunity

崔淑方

Cellular & Molecular Immunology

18(5)1235-1248

SCI(E)

a

9

Integrins as attractive targets for cancer therapeutics

王颖

Acta Pharmaceutica Sinica B

11(9): 2726-2737

SCI(E)

a

10

VEGFR2-targeted antibody fused with IFNamut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity

张娟

Acta Pharmaceutica Sinica B

11(2):420-433

SCI(E)

a

11

STING inhibitors target the cyclic dinucleotide binding pocket

王琛

Proceedings of the National Academy of Sciences of the United States of America

118(24):e2105465118

SCI(E)

a

12

Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice

金亮

Proc Natl Acad Sci U S A

117(49):31219-31230

SCI(E)

a

13

Cytosolic Protein Delivery for Intracellular Antigen Targeting Using Supercharged Polypeptide Delivery Platform

高向东

Nano Lett.

21(14):6022-6030

SCI(E)

a

14

Polysaccharides catabolism by the human gut bacterium -Bacteroides thetaiotaomicron: advances and perspectives.

刘玮

Crit Rev Food Sci Nutr.

61(21):3569-3588

SCI(E)

a

15

The interaction of SET and protein phosphatase 2A as target for cancer therapy

王淑珍

Biochim Biophys Acta Rev Cancer

1876(1):188578

SCI(E)

a

16

 A purified acidic polysaccharide from Sarcandra glabra as vaccine adjuvant to enhance anti-tumor effect of cancer vaccine.

刘玮

Carbohydr Polym.

263:117967

SCI(E)

a

17

The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma

朱娟娟

Cell Death & Disease

 

SCI(E)

a

18

Multifaceted regulation of translation by the epitranscriptomic modification N6-methyladenosine

周君

Critical Reviews in Biochemistry and Molecular Biology

56(2):137-148

SCI(E)

a

19

Development of a novel, fully human, anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy

谭树华

EBioMedicine

65:103250

SCI(E)

a

20

Diazinon exposure produces histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in crucian carp (Carassius auratus gibelio)

汤佳立

Environmental Pollution

269: 116129

SCI(E)

a

21

The Alternatively Spliced Isoforms of Key Molecules in the cGAS- STING Signaling Pathway

王琛

Frontiers in Immunology

12:1-9

SCI(E)

a

22

Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression

邢莹莹

Frontiers in Immunology

12:Article 624725

SCI(E)

a

23

The alternatively spliced isoforms of key molecules in the cGAS-STING signaling pathway

朱娟娟

Frontiers in Immunology

12:771744

SCI(E)

a

24

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

崔淑方

Frontiers in Immunology

12655637

SCI(E)

a

25

Selective enzymatic α-1,6-monoglucosylation of mogroside IIIE for the bio-creation of α-siamenoside I, a potential high-intensity sweetener

吴旭日

Food Chemistry

359: 129938.

SCI(E)

a

26

Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation

郑禄枫

J Med Chem

64(21):15702-15715.

SCI(E)

a

27

Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

马菱蔓

Computational and Structural Biotechnology Journal

19(2021)5494–5503

SCI(E)

b

28

Expression, localization and metabolic function of “resurrected” human
urate oxidase in human hepatocytes

陈建华

International Journal of Biological Macromolecules

175:30-39

SCI(E)

a

29

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

邢莹莹

Stem Cell Research & Therapy

(2021) 12:325

SCI(E)

b

30

Tumour microenvironment-based molecular profiling reveals ideal candidates for high-grade serous ovarian cancer immunotherapy

叶俊梅

Cell Prolif.

54(3):e12979

SCI(E)

b

31

RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

王琛

PLOS Pathogens

17(3)e1009401

SCI(E)

a

32

Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel

王全逸

Frontiers in Cell and Developmental Biology

9760035

SCI(E)

a

33

The Phytochemical Rhein Mediates M 6 A-Independent Suppression of Adipocyte Differentiation

周君

Frontiers in Nutrition

8:756803

SCI(E)

a

34

Prebiotic, antioxidant, and immunomodulatory properties of acidic exopolysaccharide from marine Rhodotorula RY1801

储卫华

Frontiers in Nutrition

8:710668

SCI(E)

a

35

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy.

刘畅

Drug Delivery

28(1): 594-606

SCI(E)

a

36

Oral delivery of staphylococcal nuclease ameliorates DSS induced ulcerative colitis in mice via degrading intestinal neutrophil extracellular traps

吴洁

Ecotoxicology and Environmental Safety

215:112161

SCI(E)

a

37

Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice

刘畅

Ecotoxicology and Environmental Safety

225:112802

SCI(E)

a

38

QTMP, a Novel Thiourea Polymer, Causes DNA Damage to Exert Anticancer Activity and Overcome Multidrug Resistance in Colorectal Cancer Cells

马菱蔓

Front Oncol

2021 May 28;11:667689

SCI(E)

b

39

MLK3 Is Associated With Poor Prognosis in Patients With Glioblastomas and Actin Cytoskeleton Remodeling in Glioblastoma Cells.

侯筱宇

Front Oncol.

10:600762.

SCI(E)

a

40

The Role of Iron in Cancer Progression.

郑禄枫

Front Oncol

11:778492

SCI(E)

a

41

Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution

周君

Journal of Molecular Cell Biology

13(4):325-328

SCI(E)

a

42

Intervention of cGAS-STING signaling in sterile inflammatory diseases

王琛

Journal of Molecular Cell Biology

 

SCI(E)

a

43

Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans.

储卫华

Biofactors

47(4): 686-693

SCI(E)

a

44

Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia

谭树华

Biomedicines

9(12)1783-

SCI(E)

a

45

WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency

孔毅

 

9, 1745.

SCI(E)

a

46

Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides

吴旻

International Journal of Molecular Sciences

22(11):5630

SCI(E)

a

47

Nanocarrier-based drug delivery for melanoma therapeutics

张雯翔

International Journal of Molecular Sciences

22:1873

SCI(E)

a

48

PPARs-Orchestrated Metabolic Homeostasis in the Adipose Tissue

刘畅

International Journal of Molecular Sciences

22:8974

SCI(E)

a

49

DAKS1, a Kunitz Scaffold Peptide from the Venom Gland of Deinagkistrodon acutus Prevents Carotid-Artery and Middle-Cerebral-Artery Thrombosis via Targeting Factor Xia

孔毅

Pharmaceuticals

14, 966.

SCI(E)

a

50

Helicobacter pylori induces gastric cancer via down-regulating  miR-375 to inhibit dendritic cell maturation

邢莹莹

Helicobacter

2021;00:e12813.1-13

SCI(E)

a

51

Oral multivalent epitope vaccine, based on UreB, HpaA, CAT, and LTB, for prevention and treatment of Helicobacter pylori infection in C57BL / 6 mice

赵文锋

Helicobacter

26(3):e12807

SCI(E)

a

52

LncRNA CTD-3252C9.4 modulates pancreatic cancer cell survival and apoptosis through regulating IFI6 transcription

潘怡

Cancer Cell International

21(1):433

SCI(E)

a

53

The Regulatory Network of cGAS-STING Pathway in Viral Evasion

王全逸

Frontiers in microbiology

 

SCI(E)

a

54

cGAS-STING pathway: post-translational modifications and functions in sterile inflammatory diseases

王琛

FEBS Journal

STATE-OF-THE-ART-REVIEW

SCI(E)

a

55

MSI-1 combats drug-resistant S. aureus by affecting bacterial viability and inhibiting carotenoid pigment production

周长林

Microbiol Res

27;255:126909

SCI(E)

a

56

Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/ STAT3 signaling

李睿岩

phytomedicine

84 (2021) 153519

SCI(E)

a

57

Biliary microbial structure of gallstone patients with a history of endoscopic sphincterotomy surgery

朱娟娟

Frontiers in Cellular and Infection Microbiology

10: 594778

SCI(E)

b

58

Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors

陆园园

BIOORGANIC CHEMISTRY

109:104736

SCI(E)

a

59

MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer's disease.

高向东

Neuropharmacology.

196:108671

SCI(E)

a

60

Influence of fluconazole administration on gut microbiome, intestinal barrier and immune response in mice

储卫华

Antimicrobial agents and chemotherapy

65(6): e02552-20

SCI(E)

a

61

Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

侯筱宇

FASEB J.

35(8):e21769

SCI(E)

a

62

A Multi-epitope Peptide rOmp22 Encapsulated in Chitosan-PLGA Nanoparticles as Vaccine Candidate Against Acinetobacter baumannii Infection

薛建鹏

International Journal of Nanomedicine

16: 1819–1836

SCI(E)

b

63

Vascular endothelial growth factor B exerts lipid-lowering effect by activating AMPK via VEGFR1

童玥

 Life Sciences

276:119401

SCI(E)

a

64

Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice

张玉彬

Life Sci

281(2021):119778

SCI(E)

a

65

Convenient Genetic Encoding of Phenylalanine Derivatives through Their α-Keto Acid Precursors

宋潇达

Biomolecules

11(9):1358

SCI(E)

a

66

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis

邢莹莹

Environmental Toxicology

2021;1–9.

SCI(E)

b

67

HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

郑禄枫

Mol Carcinog

60(6):413-426.

SCI(E)

a

68

Cysteine-Based Coupling: Challenges and Solutions

张娟

Bioconjugate chemistry

32(8):1525-1534

SCI(E)

a

69

Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells

马菱蔓

Biochim Biophys Acta Mol Cell Res

2021 Nov 20;1869(2):119174

SCI(E)

b

70

GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice.

侯筱宇

Neurobiol Aging.

108:47-57

SCI(E)

a

71

Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation

周君

RNA Biology

18(9):1354-1363

SCI(E)

a

72

PCL-1, a Trypsin-Resistant Peptide, Exerts Potent Activity Against Drug-Resistant Bacteria

马菱蔓

Probiotics Antimicrob Proteins

13(5):1467-1480

SCI(E)

a

73

Weissella confusa CGMCC 19,308 strain protects against oxidative stress, increases lifespan, and bacterial disease resistance in Caenorhabditis elegans

储卫华

Probiotics and Antimicrobial Proteins

20211-9

SCI(E)

a

74

PCL-1, a Trypsin-Resistant Peptide, Exerts Potent Activity Against Drug-Resistant Bacteria

马菱蔓

Probiotics Antimicrob Proteins

13(5):1467-1480

SCI(E)

a

75

An antitumor peptide RS17-targeted CD47, design, synthesis, and antitumor activity

王颖

Cancer Medicine

10(6):2125-2136

SCI(E)

b

76

A phycocyanin derived eicosapeptide attenuates lung fibrosis development.

欧瑜

Eur J Pharmacol

908:174356

SCI(E)

a

77

Sinomenine ameliorates septic acute lung injury in mice by modulating gut homeostasis via aryl hydrocarbon receptor/Nrf2 pathway

黄凤杰

European Journal of Pharmacology

912 (2021) 174581

SCI(E)

a

78

Review: Inhibitory potential of low molecular weight Heparin in cell adhesion; emphasis on tumor metastasis

何书英

European Journal of Pharmacology

892:173778.

SCI(E)

a

79

Inhibition of PAD4-mediated NET formation by clamidine prevents diabetes development in nonobese diabetic mice

吴洁

Eur J Pharmacol

 

SCI(E)

a

80

Biased agonists with less glucagon-like peptide-1 receptor-mediated endocytosis prolong hypoglycaemic effects.

高向东

Eur J Pharmacol.

907:174203

SCI(E)

a

81

An oral GLP-1 and GIP dual receptor agonist improves metabolic disorders in high fat-fed mice.

高向东

Eur J Pharmacol.

17:174635.

SCI(E)

a

82

Continuous stimulation of dual-function peptide PGLP-1-VP inhibits the morbidity and mortality of NOD mice through anti-inflammation and immunoregulation

张艳峰

Scientific Reports

11(1): 3593-3593

SCI(E)

a

83

Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms

刘玮

Journal of Ethnopharmacology

 264, 113280

SCI(E)

b

84

Study on performance of mimic uricase and its application
in enzyme-free analysis

陈建华

Analytical and Bioanalytical Chemistry

413(26):6571-6580

SCI(E)

a

85

Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods

薛建鹏

Scientific Reports

11: 2282.

SCI(E)

a

86

EGLP-1 lowers body weight better than exendin-4 by reducing food intake and increasing basal energy expenditure in diet-induced obese mice

金亮

Experimental Cell Research

399(1): 112454-112464

SCI(E)

a

87

A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells

何书英

Investigational new drugs

39:1222–1231

SCI(E)

a

88

Analysis of Differentially Expressed Genes That Aggravate Metabolic Diseases in Depression

刘畅

Life

11: 1203

SCI(E)

a

89

CD4+ CD8αα+ T cells in the gastric epithelium mediate chronic inflammation induced by Helicobacter felis

邢莹莹

Microbial Pathogenesis

(2021) 159:105151

SCI(E)

a

90

Identification of choline-degrading bacteria from healthy human feces and used for screening of trimethylamine (TMA)-lyase inhibitors

储卫华

Microbial Pathogenesis

152, 104658

SCI(E)

a

91

Improved oral delivery of insulin by PLGA nanoparticles coated with 5 β-cholanic acid conjugated glycol chitosan

金亮

BIOMEDICAL MATERIALS

16(6):064103

SCI(E)

a

92

Immunomodulatory effects of platelets on the severity of hand, foot, and mouth disease infected with enterovirus 71.

郭薇

Pediatr Res.

89(4):814-822

SCI(E)

a

93

Influence of butyrate on the pathogenicity of Aeromonas hydrophila

储卫华

Aquaculture Nutrition

2021;00:1–7.

SCI(E)

a

94

Efficient whole-cell biosynthesis of L-gulose by coupling mannitol-1-dehydrogenase with NADH oxidase

吴旭日

Enzyme and Microbial Technology

148: 109815

SCI(E)

a

95

“Resurrected” human-source urate oxidase with high uricolytic activity
and stability

陈建华

Enzyme and Microbial Technology

149:109852

SCI(E)

a

96

An antitumor peptide RS17-targeted CD47, design, synthesis, and antitumor activity

王颖

Cancer Medicine

2021, 10(6): 2125-2136

SCI(E)

b

97

Potent antibacterial and antibiofilm activities of TICbf-14, a peptide with increased stability against trypsin

周长林

Journal of Microbiology

 (2022) Vol. 60

SCI(E)

a

98

Demethylenetetrahydroberberine Protects Dopaminergic Neurons in Mouse Model of Parkinson’s Disease

张玉彬

Chinese Journal of Natural Medicines

 2021, 19(x): 1-10

SCI(E)

a

99

Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications

马菱蔓

Zhejiang Univ-Sci B (Biomed & Biotechnol)

online

SCI(E)

b

100

Regulation of RDN on Th1/ILC1 cell imbalance in HFMD patients caused by EV71 infection.

郭薇

Chin J Nat Med.

19(3):205-211.

SCI(E)

a

101

The efficacy and safety of Nivolumab combined with Ipilimumab in the immunotherapy of cancer: a meta-analysis

张娟

Immunopharmacology and Immunotoxicology

43(3):386-394

SCI(E)

a

102

Strategies to Increase the Production of Biosynthetic Riboflavin

郑珩

Mol Biotechnol

63(10):909-918

SCI(E)

a

103

Changes in the gut microbiota: a possible factor influencing peripheral blood immune indexes in non-obese diabetic mice

吴洁

Antonie van Leeuwenhoek

 

SCI(E)

a

104

Genome mining of secondary metabolites from a marine-derived Aspergillus terreus B12

王颖

Archives of Microbiology

203(9):5621-5633

SCI(E)

a

105

Establishment and optimization of a high-throughput mimic perfusion model in ambr ®

曹荣月

Biotechnol Lett

43(2):423-433

SCI(E)

a

106

Genome sequence of Aspergillus flavus A7, a marine-derived fungus with antibacterial activity

王颖

Genome

64(7):719-733

SCI(E)

a

107

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

曾科

NATURE COMMUNICATIONS

(2021) 12:2030

SCI(E)

a

108

PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23

曾科

Cell Mol Immunol

18(8):2048-2050

SCI(E)

a

109

Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice.

陈思禹

Gut Microbes

13(1): 1946369

SCI(E)

a

110

Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-
Associated Colon Cancer via Inhibiting Immune Tolerance

张昕

Cellular and Molecular Gastroenterology and Hepatology

12(4):1179–1199

SCI(E)

a

111

Phycocyanin-functionalized black phosphorus quantum dots enhance PDT/PTT therapy by inducing ROS and irreparable DNA damage.

郭长缨

BiomaterialSciences

9:5302-5318

SCI(E)

a

112

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

宋明明

International Journal of Molecular Sciences

22:9118

SCI(E)

a

113

Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

陈思禹

International Journal of Molecular Sciences

22(11):6110

SCI(E)

a

114

The multiple regulation of metastasis suppressor NM23-H1 in cancer

郭长缨

Life Sciences

268, 118995-119002

SCI(E)

a

115

Crosstalk between macrophages and natural killer cells in the tumor microenvironment

郭长缨

nternational Immunopharmacolog

12, 108374-108390.

SCI(E)

a

116

HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

奚涛

Mol Carcinog

60(6):413-426.

SCI(E)

a

117

Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers

陈依军

Sci Rep

11(1):8017

SCI(E)

a

118

Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats

陈依军

Drug Des Devel Ther

15:3487-3498

SCI(E)

a

119

Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis.

奚涛

Environ Toxicol

 

SCI(E)

a

120

Toll-Like Receptors Regulate the Development and Progression of Renal Diseases

曾科

Kidney Dis

7(1):14-23

SCI(E)

a

121

分子伴侣蛋白介导的革兰阴性菌耐酸机制研究进展

刘楠

中国药科大学学报

52(2): 164-170

北核

a

122

线粒体DNA与cGAS-STING固有免疫信号通路的研究前沿

王琛

四川大学学报(医学版)

52(3): 387-395

北核

a

123

基质血管组分(SVF)临床分离技术研究

金亮

中国细胞生物学学报

43(1):73-82

CSCD

a

124

LncRNA 与肝脏糖脂代谢的研究进展

吴洁

生物工程学报

36(1): 1−13

北核

a

125

LAG-3的免疫学功能及其抗体药物的研究进展

曹荣月

中国细胞生物学学报

2021,43(02):484-492

CSCD

a

126

凝血因子Ⅶ及其重组表达新进展

曹荣月

中国生物工程杂志

2021,41(Z1):129-137.

北核

b

127

乳腺癌代谢重编程与微环境重塑的研究进展

高向东

中国药科大学学报

52(02):156-163.

北核

a

128

信号肽在大肠杆菌分泌系统中的研究与应用进展

高向东

中国生物工程杂志

41(05):87-93

北核

b

129

1型糖尿病治疗研究进展

金亮

沈阳药科大学学报

38(06),643-648

北核

a

130

非编码RNA与胰岛素信号通路关系及其临床应用

金亮

中国药科大学学报

52(03),279-286

北核

a

131

抑制剂对鱼藤酮所致帕金森病秀丽隐杆线虫模型的影响

陈松

中国药科大学学报

52(03):346-351

北核

a

132

PD-L1和VEGF双靶点联合阻断治疗的研究进展

徐寒梅

中国生物工程杂志

41(09):71-77

北核

a

133

重组甜味蛋白Monellin在E.coli中的表达条件及其对ICR小鼠血糖的影响

曹荣月

中国调味品

2021,46(07):1-6

北核

a

134

小开放阅读框编码微肽的研究进展

徐寒梅

遗传

43(08):737-746

北核

a

135

免疫检查点B7-H3表位疫苗的设计及其抗肿瘤活性

田浤

中国药科大学学报

52(04):472-479

北核

a

136

microRNA-23b对Aβ_(25-35)导致神经细胞凋亡的作用及机制研究

姚文兵

中国药科大学学报

52(04):480-486

北核

a

137

染色体外环状DNA的研究进展

梁宏伟

中国细胞生物学学报

43(12)

CSCD

a

138

肿节风多糖SGP-2的高级结构解析及构效关系研究

高向东

中国药科大学学报

52(05):630-635.

北核

a

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