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2022年主要科研成果

 

1.专利情况

序号

专利名称

专利授权号

获准国别

完成人

类型

类别

1

Crystal forms of Demethyleneberberine hydrochloride and preparation method therefor

US11242340 B2

美国

张玉彬

发明专利

合作完成-第一人

2

抗TNF-a/PD-1双特异性抗体及其应用

ZL202010870619.3

中国

刘煜

发明专利

合作完成-第一人

3

一种赛门苷 I 的纯化制备方法

ZL202110544460.0

中国

吴旭日

发明专利

合作完成-第一人

4

盐酸去亚甲基四氢小檗碱晶型及其制备方法

ZL202010651059.2

中国

张玉彬

发明专利

合作完成-第一人

5

2位取代蒽醌衍生物在制备治疗白色念珠菌感染药物中的应用

ZL202010849420.2

中国

陆园园

发明专利

合作完成-第一人

6

抗肿瘤靶向融合蛋白、其偶联物及用途

ZL201811632324.1

中国

高向东

发明专利

合作完成-第一人

7

CPUL1脂质体及其制备方法

ZL202110493959.3

中国

陆园园

发明专利

合作完成-第一人

8

一种抗菌多肽HF-18及其制备方法和应用

ZL201910162027.3

中国

周长林

发明专利

合作完成-第一人

9

蓝藻抗病毒蛋白N在制备抗炎药物中的应用

ZL202010391561.4

中国

欧瑜

发明专利

合作完成-第一人

10

一株具有抗菌抗氧化活性魏斯氏菌菌株及应用

ZL2020102353022

中国

储卫华

发明专利

合作完成-第一人

11

一种藻蓝蛋白肽在制备抗肺纤维化药物中的应用

ZL201911264468.0

中国

欧瑜

发明专利

合作完成-第一人

12

一种靶向c-Met的多肽及其应用

ZL2019112899887

中国

徐寒梅

发明专利

合作完成-第一人

13

抗人ISG15蛋白抗体基因及其利用

ZL201910038977.5

中国

王琛

发明专利

合作完成-第一人

14

一种EphB2小分子抑制剂及其用途

ZL202010811142.1

中国

王淑珍

发明专利

合作完成-第一人

15

一种口服降糖肽在制备治疗或预防糖尿病并发心血管疾病药物中的应用

ZL202010853498.1

中国

高向东

发明专利

合作完成-第一人

16

一种具有抗CD47免疫检查点拮抗活性的多肽RS-17及其应用

ZL2019112647227

中国

徐寒梅

发明专利

合作完成-第一人

17

一种抗菌多肽SA-2及其制备方法和应用

ZL202110293357.3

中国

周长林

发明专利

合作完成-第一人

18

一种PD-1靶向阻断肽及其应用

ZL202010058292.X

中国

邱郑

发明专利

合作完成-第一人

19

一种抑制肿瘤生长的基因工程菌及其构建方法和应用

ZL2016101450457

中国

徐寒梅

发明专利

合作完成-第一人

20

小分子化合物1-苄基咪唑在治疗乳腺癌中的应用

CN202110126433.1

中国

郑禄枫

发明专利

合作完成-第一人

21

一种用于多发性骨髓瘤的双特异性抗体及其应用

202011079622.X

中国

张娟

发明专利

合作完成-第一人

22

一种组合物及其在制备皮肤修复产品中的应用

ZL202010069646.0

中国

欧瑜

发明专利

合作完成-第一人

23

新型诺西肽糖基化衍生物及其制备方法和应用

ZL202010921312.1

中国

吴旭日

发明专利

合作完成-第一人

24

ROCK2抑制剂在制备药物中的用途

ZL201711383699.4

中国

张昕

发明专利

合作完成-第二人

25

尖吻蝮蛇抗凝血因子XI多肽及其应用

ZL2012111106060.8

中国

孔毅

发明专利

合作完成-第一人

26

抗人DLL4人源化抗体与海兔毒素衍生物MMAE的偶联物及其制备方法与应用

ZL 202010429398.6

中国

吴旻

发明专利

合作完成-第一人

27

苯磺酰胺类化合物的医药用途及其药物组合物

ZL202011070259.5

中国

王琛

发明专利

合作完成-第一人

28

一种长链非编码RNA RP11-499F3.2在逆转肿瘤西妥昔单抗耐药治疗中的应用

ZL201811214096.6

中国

徐寒梅

发明专利

合作完成-第一人

29

一种非编码RNA生物标志物lnc-Wdr5的应用

ZL202110097928.6

中国

金亮

发明专利

合作完成-第一人

30

脐带间充质干细胞在预防病毒感染所致肺部疾病中的应用

ZL202211002364.4

中国

郭薇

发明专利

合作完成-第二人

31

多肽及其在制备抗神经退行性疾病药物方面的应用

ZL202110827432.X

中国

高向东

发明专利

合作完成-第一人


2.发表论文、专著情况

序号

论文或

专著名称

作者

刊物、出版社名称

卷、期

(或章节)、页

类型

类别

1

Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma

徐寒梅

Molecular Cancer

 

SCI(E)

a

2

Characterization of urethritis-associated Neisseria meningitidis isolated from men who have sex with women in China

储卫华

JOURNAL OF INFECTION

84(5):e87-e88

SCI(E)

a

3

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

徐寒梅

Signal Transduction and Targeted Therapy

 

SCI(E)

a

4

Anchoring a Xenogeneic Antigen-Guided Immune Activation System to Tumor Cell Membrane for Solid Tumor Treatment

陈欢

Advanced functional materials

32(22) - 2111499.1-2111499.11

SCI(E)

a

5

 DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides.

劳兴珍

Nucleic Acids Res

50(D1):D488-D496

SCI(E)

a

6

UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation

王琛

Autophagy

1-17

SCI(E)

a

7

Tailored protein-conjugated DNA nanoplatform for synergistic cancer therapy

高向东

Journal of Controlled Release

346:250-259

SCI(E)

a

8

Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers

宋明明

Journal of Controlled Release

345: 744-754

SCI(E)

a

9

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

徐寒梅

Cancer Letters

547:215723

SCI(E)

a

10

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer.

金亮

Cell Death Dis

13(2):95.

SCI(E)

a

11

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

李丽民

Cell Death Dis

13(3):281

SCI(E)

a

12

Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice

徐寒梅

CELL DEATH & DISEASE

13(4):305

SCI(E)

a

13

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2

张昕

CELL DEATH & DISEASE

2022, 13(2):138

SCI(E)

a

14

The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma

朱娟娟

Cell Death & Disease

13(1): 15

SCI(E)

a

15

Targeted disruption of mitochondria potently reverses multidrug resistance in cancer therapy

尹骏

British Journal of Pharmacology

179(13):3346-3362

SCI(E)

a

16

Obesity-induced miR-455 upregulation promotes adaptive pancreatic β-cell proliferation through the CPEB1/CDKN1B pathway

金亮

diabetes

71(3): 394-411.

SCI(E)

a

17

Enzymatic hydrolyzation of mogrosides in Luo Han Guo extract by NKA-adsorbed snailase improves its sensory profile

吴旭日

Food Chemistry

390: 133205

SCI(E)

a

18

METTL3 modulates chromatin and transcription dynamics during cell fate transition

刘晓敏

Cellular and Molecular Life Sciences

79(11):559

SCI(E)

a

19

Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis

郑禄枫

CELLULAR AND MOLECULAR LIFE SCIENCES

79(7):360

SCI(E)

b

20

Identification of the c-Jun/H19/miR-19/JNK1 cascade during hepatic stellate cell activation.  (accepted)

刘明慧

Clinical and Translational Medicine.

 

SCI(E)

a

21

Hordb a comprehensive database of peptide hormones

劳兴珍

Scientific Data,

2022, 9:187

SCI(E)

a

22

Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis

李菁

npj Biofilms and Microbiome

8(1):11

SCI(E)

a

23

ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning.

侯筱宇

Neuropsychopharmacology

47(7):1292-1303.

SCI(E)

a

24

Intervention of cGAS-STING signaling in sterile inflammatory diseases

王琛

Journal of Molecular Cell Biology

14(2):mjac005

SCI(E)

a

25

Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization.

尹骏

Journal Of Medicinal Chemistry

2022 Nov 22.

SCI(E)

a

26

Preparation and characterization of 2-deacetyl-3-O-sulfo-heparosan and its antitumor effects via the fibroblast growth factor receptor pathway

查正其

International Journal of Biological Macromolecules

201 (2022) :47–58

SCI(E)

a

27

Heparosan-based self-assembled nanocarrier for zinc(II) phthalocyanine for use in photodynamic cancer therapy

查正其

International Journal of Biological Macromolecules

219 (2022) :31–43

SCI(E)

a

28

A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice

欧瑜

FOOD SCI HUM WELL

011(006):1544-1554

SCI(E)

a

29

Obesity and insulin resistance: Pathophysiology and treatment

童玥

Drug Discovery Today

27(3):822-830

SCI(E)

a

30

Synthesis and Evaluation of Antioxidant and Potential Prebiotic Activities of Acetylated and Butyrylated Fructo-Oligosaccharides

朱卫

ANTIOXIDANTS

11(9): 1658.

SCI(E)

a

31

Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice

吴洁

Front Immunol

12:711423

SCI(E)

a

32

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis

曾科

Mol Ther Oncolytics

25:276-287

SCI(E)

a

33

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

叶俊梅

Clinical Sci ence (Lond)

136(22):1711-1730

SCI(E)

a

34

SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart

叶俊梅

Cell Biol Toxicol.

Online ahead of print

SCI(E)

a

35

Rhein ameliorates septic lung injury and intervenes in macrophage metabolic reprogramming in the inflammatory state by Sirtuin 1

黄凤杰

Life Sciences

310 (2022): 121115

SCI(E)

a

36

Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects

孔毅

Life Sciences

309 (2022): 121021

SCI(E)

a

37

A bovine milk-derived peptide ameliorates alloxan-injured pancreatic β cells through IRS2/PI3K/Akt signaling.

欧瑜

LIFE SCI

 

SCI(E)

a

38

Inhibitors of protease-activated receptor 4 (PAR4): a review of recent patents (2013–2021)

孔毅

Expert Opinion on Therapeutic Patents

 32(2: 153–170

SCI(E)

b

39

Dynamic Transcriptome Profiling Reveals LncRNA-Centred Regulatory Networks in the Modulation of Pluripotency

刘晓敏

Frontiers in Cell and Developmental Biology

10:880674

SCI(E)

a

40

Demethylzeylasteral attenuates hepatic stellate cell activation and liver fibrosis by inhibiting AGAP2 mediated signaling

王淑珍

Phytomedicine

105: 154349

SCI(E)

a

41

VEGFR2-MICA fusion antibodies enhance immunotherapy effect and synergize with PD-1 blockade

张娟

 

 

SCI(E)

a

42

 Berberine Ameliorates Inflammation in Acute Lung Injury via NF-kBNlrp3 Signaling Pathway

卞筱泓

FRONTIERS IN NUTRITION

9:851255

SCI(E)

a

43

Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (Hippophae rhamnoides L.)

储卫华

FRONTIERS IN NUTRITION

9:861097

SCI(E)

a

44

Endothelial-Specific Molecule 1 Inhibition Lessens Productive Angiogenesis and Tumor Metastasis to Overcome Bevacizumab Resistance

纪雪梅

Cancers

14(22), 5681

SCI(E)

a

45

The multiple effects of REG1 deletion and SNF1 overexpression improved the production of S-adenosyl-l-methionine in Saccharomyces cerevisiae

马菱蔓

Microbial Cell Factories

21(1):174

SCI(E)

b

46

Recombinant Reg3α prevents islet β-cell apoptosis and promotes β-cell regeneration

罗晨

International Journal of Molecular Science

23(18): 10584

SCI(E)

b

47

A novel method to purify small RNAs from human tissues for methylation analysis by LC-MS/MS

梁宏伟

Front Mol Biosci

9:949181

SCI(E)

a

48

Strongylocentrotus nudus Eggs Polysaccharide Enhances Macrophage Phagocytosis Against E.coli Infection by TLR4/STAT3 Axis

樊竑冶

Frontiers in Pharmacology

13:807440

SCI(E)

a

49

A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo

周长林

Frontiers in Pharmacology

2022(13)

SCI(E)

a

50

The roles and targeting options of TRIM family proteins in tumor

郑禄枫

Frontiers in pharmacology

13:999380

SCI(E)

a

51

Engineering of a UDP-Glycosyltransferase for the Efficient Whole-Cell Biosynthesis of Siamenoside I in Escherichia coli

吴旭日

Journal of Agricultural and Food Chemistry

 70: 1601-1609

SCI(E)

a

52

beta-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE(-/-) mice

储卫华

FRONTIERS IN CARDIOVASCULAR MEDICINE

9:986905

SCI(E)

a

53

Blocking CD47 Shows Superior Anti-tumor Therapeutic Effects of Bevacizumab in Gastric Cancer

刘煜

Frontiers of Pharmacology

13, 880139

SCI(E)

a

54

MD2 Is a Potential Biomarker Associated with Immune Cell Infiltration in Gliomas

王淑珍

FRONTIERS IN ONCOLOGY

12:854598

SCI(E)

a

55

Research progress on RNA-binding proteins in breast cancer

郑禄枫

Frontiers in oncology

12:974523

SCI(E)

a

56

Genomic Analysis and Antimicrobial Components of M7, an Aspergillus terreus Strain Derived from the South China Sea

王颖

Journal of Fungi

8 (10): 1051

SCI(E)

a

57

Genomic and Chemical Profiling of B9, a Unique Penicillium Fungus Derived from Sponge

陆园园

Journal of Fungi

8 (7): 686

SCI(E)

a

58

Demethyleneberberine blocked the maturation of IL-1Beta in inflammation by inhibiting TLR4-mitochondria signaling.

李睿岩

 International immunopharmacology

113:109319

SCI(E)

a

59

Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion

丁明

Journal of Biological Chemistry

 

SCI(E)

a

60

Lactobacillus salivarius CPU-01 Ameliorates Temozolomide-Induced Intestinal Mucositis by Modulating Gut Microbiota, Maintaining Intestinal Barrier, and Blocking Pro-inflammatory Cytokines

储卫华

Probiotics Antimicrob Proteins.

1–10

SCI(E)

a

61

Weissella confusa CGMCC 19,308 Strain Protects Against Oxidative Stress, Increases Lifespan, and Bacterial Disease Resistance in Caenorhabditis elegans

储卫华

Probiotics Antimicrob Proteins.

14(1):121-129.

SCI(E)

a

62

Reprogramming the Biosynthesis of Precursor Peptide to Create a Selenazole-Containing Nosiheptide Analogue

陈依军

ACS SYNTHETIC BIOLOGY

11(1):85-91

SCI(E)

a

63

Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis.

金亮

World J Stem Cells

14(10):744-755

SCI(E)

a

64

Silk fibroin hydrolysate improves memory impairment via multi-target function

高向东

Journal of Functional Foods

89, 104942

SCI(E)

a

65

Fragments of a pectin from Arctium lappa L: Molecular properties and intestinal regulation activity

高向东

Journal of Functional Food

88, 104900

SCI(E)

a

66

Gypenoside XLIX Ameliorate High-Fat Diet-Induced Atherosclerosis via Regulating Intestinal Microbiota, Alleviating Inflammatory Response and Restraining Oxidative Stress in ApoE-/- Mice

储卫华

Pharmaceuticals

15, 1056

SCI(E)

a

67

Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice

高向东

Journal of Ethnopharmacology

293,115,262

SCI(E)

a

68

Integrating transcriptomics and metabolomics analysis on kojic acid combating Acinetobacter baumannii biofilm and its potential roles

王颖

Microbiological Research

254: 126911-126924

SCI(E)

a

69

Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury

曾科

Biomedicines

10(5):1193

SCI(E)

a

70

SCFAs improve disease resistance via modulate gut microbiota, enhance immune response and increase antioxidative capacity in the host

储卫华

FISH & SHELLFISH IMMUNOLOGY

120:560-568.

SCI(E)

a

71

Prognostic Value and Potential Regulatory Mechanism of H19 in Stomach Adenocarcinoma

刘明慧

Journal of Oncology.

Volume 2022, Article ID 7702626, 12 pages.

SCI(E)

b

72

Interaction between Plasma Metabolomics and Intestinal Microbiome in db/db Mouse, an Animal Model for Study of Type 2 Diabetes and Diabetic Kidney Disease

吴洁

Metabolites

12(9)

SCI(E)

a

73

Exploring of probiotic potential vaginal lactobacillus isolates from healthy women against Gardnerella vaginalis and Caenorhabditis elegans model testing

储卫华

JOURNAL OF APPLIED MICROBIOLOGY

133(3):1392-1401.

SCI(E)

a

74

2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae

陆园园

RESEARCH IN MICROBIOLOGY

173(6-7):103955

SCI(E)

b

75

Centranthera grandiflore alleviate alcohol-induced oxidative stress and cell apoptosis

戚微岩

Chinese Journal of Natural Medicines

20(7): 1-8

SCI(E)

a

76

Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson’s disease

张玉彬

Chinese Journal of Natural Medicines

 20(2): 111-119

SCI(E)

a

77

Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish

储卫华

MICROBIAL PATHOGENESIS

163:105387.

SCI(E)

a

78

An active domain SA2 derived from cystatinSA, and its antifungal activity

周长林

Amino Acids

2022 Nov 4

SCI(E)

a

79

Prediction of cellular targets in diabetic kidney diseases with singlecell transcriptomic analysis of db/db mouse kidneys

吴洁

Journal of Cell Communication and Signaling

 

SCI(E)

a

80

Development and validation of a liquid chromatography‐tandem mass spectrometry method for CPUL1, a novel antitumor candidate compound, and its application to pharmacokinetic studies

陆园园

Journal of Separation Science

45(22)

SCI(E)

a

81

 IL-6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis

叶俊梅

Biochem Biophys Res Commun.

603:144-152

SCI(E)

a

82

Obesity induced Ext1 reduction mediates the occurrence of NAFLD

金亮

Biochem Biophys Res Commun.

589:123-130

SCI(E)

a

83

Neuroscience Letters

张玉彬

Neuroscience Letters

 785 (2022) 136770

SCI(E)

a

84

Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis

李丽民

Kidney Dis

8(4):308-318

SCI(E)

b

85

Potent antibacterial and antibiofilm activities of TICbf-14, a peptide with increased stability against trypsin

周长林

Journal of Microbiology

60(1):89-99

SCI(E)

a

86

Probiotics for the Treatment of Gastric Diseases

邢莹莹

Nutrition and Cancer

74 (9) :3051-3057

SCI(E)

a

87

A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production

王颖

Molecular Biology Reports

49: 8835–8845

SCI(E)

a

88

Physicochemical Characterization of Berberineloaded Pluronic F127 Polymeric Micelles and In Vivo Evaluation of Hypoglycemic Effect

黄凤杰

Journal of Pharmaceutical Innovation

2022:1-10

SCI(E)

a

89

Antibacterial Activities of Peptide HF18 Against Helicobacter pylori and its Virulence Protein CagA

周长林

International Journal of Peptide Research and Therapeutics

(2022) 28:63

SCI(E)

a

90

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria.

朱卫

Journal of visualized experiments : JoVE

184(e64201):1-6

SCI(E)

a

91

纳米制剂在糖尿病创面愈合中的应用研究

吴洁

中国药科大学学报

1:25-31

北核

a

92

虾青素临床研究现状及其在特医食品开发中的应用前景

吴洁

中国海洋药物

41(4):89-94

CSCD

a

93

过表达核苷二磷酸激酶对透明质酸产量和相对分子质量的影响

虞菊萍

中国药科大学学报

 53(2): 232-238

北核

a

94

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